AAGBI/Anaesthesia Small Research Grant
The successful applicant for the AAGBI/Anaesthesia Small Research Grant was:
Principal Applicant:
Dr BV Patel Anaesthetics, Pain Medicine and Intensive Care, Imperial College London.
Title of Project:
Cellular and molecular mechanisms of aspiration induced lung injury.
Amount
£14,915
Abstract:
Acid aspiration is a major cause of acute lung injury and has a significant associated morbidity and mortality. We have shown in an in vivo mouse model of acid-induced lung injury that the development of pulmonary oedema is specifically mediated through the p55 tumour necrosis factor (TNF) receptor and attenuated by its p75 receptor. This novel concept of differential TNF receptor signalling in acute lung injury may provide future therapeutic targets. Using genetically modified mice, we propose to investigate the mechanisms leading to these differential effects, focussing particularly on the monocyte-mediated and coagulation pathway-mediated mechanisms within acid-induced lung injury.
Final Report from Dr B Patel.pdf (377 KB)
Please see the NIAA's position statement on the use of animals in medical research.
